See, in this episode, Bernard and Rose go visit a mystic healer named Isaac of Uluru. They want to have Rose's cancer cured (which actually happens on the island), and this guy supposedly can do that.
On Heroes, a prophetic painter named Isaac paints a comic book cover (above) with a rock-like monster named Uluru.
Also, the new Lost ARG has begun at http://www.lostuniversity.org. While I'm not much for Alternative Reality Games, I did read Bad Twin (from a few years back) and really like this logo.